Marianne Pavel Selected Research

Tryptophan Hydroxylase

1/2022	Efficacy, safety and unmet needs of evolving medical treatments for carcinoid syndrome.
1/2019	Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome.
1/2018	Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome.
1/2018	Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial.
11/2017	Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl.
1/2017	Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

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Marianne Pavel Research Topics

Disease

38	Neuroendocrine Tumors (Neuroendocrine Tumor) 06/2022 - 03/2008
38	Neoplasms (Cancer) 04/2022 - 08/2005
16	Carcinoid Tumor (Carcinoid) 01/2022 - 09/2012
8	Diarrhea 01/2022 - 07/2014
6	Disease Progression 01/2021 - 01/2010
6	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2010
6	Primitive Neuroectodermal Tumors (PNET) 10/2016 - 12/2011
5	Carcinoid Heart Disease 01/2018 - 01/2010
2	Weight Gain 10/2021 - 01/2018
2	Neuroendocrine Carcinoma 01/2021 - 01/2017
2	Nausea 01/2018 - 01/2017
2	Flushing 01/2018 - 04/2015
1	Thyroid Neoplasms (Thyroid Cancer) 04/2022
1	Diabetes Mellitus 12/2021
1	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 12/2021
1	Thyroid Diseases (Thyroid Disease) 12/2021
1	Pneumonia (Pneumonitis) 08/2021
1	Prostatic Neoplasms (Prostate Cancer) 07/2021
1	Paraganglioma (Paragangliomas) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Multiple Endocrine Neoplasia Type 1 01/2021
1	Pheochromocytoma 01/2021
1	COVID-19 08/2020
1	Acromegaly 01/2019
1	Abdominal Pain (Pain, Abdominal) 01/2018
1	Weight Loss (Weight Reduction) 01/2018
1	Hyperglycemia 01/2018
1	Stomatitis 01/2018
1	Lymphatic Metastasis 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Infections 01/2018
1	Neutropenia 12/2017
1	Lymphopenia (Lymphocytopenia) 12/2017
1	Thrombocytopenia (Thrombopenia) 12/2017
1	Malnutrition (Nutritional Deficiencies) 01/2017
1	Gastro-enteropancreatic neuroendocrine tumor 09/2016

Drug/Important Bio-Agent (IBA)

18	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 01/2022 - 03/2008
11	telotristat ethylIBA 01/2022 - 01/2017
11	Biomarkers (Surrogate Marker)IBA 01/2021 - 03/2011
9	Everolimus FDA Link 08/2021 - 03/2011
7	Peptide Receptors (Peptide Receptor)IBA 06/2022 - 01/2011
7	Chromogranin AIBA 01/2019 - 01/2010
6	Radioisotopes (Radionuclides)IBA 06/2022 - 01/2020
6	Tryptophan HydroxylaseIBA 01/2022 - 01/2017
6	Serotonin (5 Hydroxytryptamine)IBA 01/2022 - 04/2015
6	Somatostatin Receptors (Somatostatin Receptor)IBA 01/2022 - 07/2014
6	Pharmaceutical PreparationsIBA 08/2021 - 07/2015
4	TOR Serine-Threonine KinasesIBA 08/2021 - 01/2011
4	Phosphotransferases (Kinase)IBA 01/2021 - 01/2011
4	Biological ProductsIBA 01/2021 - 03/2008
3	Interferon-alpha (Interferon Alfa)IBA 01/2022 - 08/2005
3	lanreotide (Somatuline)FDA Link 07/2021 - 07/2014
3	Edotreotide (SMT 487)IBA 01/2020 - 01/2010
3	Octreotide (Sandostatin)FDA LinkGeneric 01/2019 - 08/2005
2	EnzymesIBA 01/2022 - 01/2017
2	Hormones (Hormone)IBA 01/2022 - 07/2014
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021 - 01/2010
2	Phosphopyruvate Hydratase (Enolase)IBA 01/2019 - 12/2011
2	Hydroxyindoleacetic AcidIBA 01/2018 - 01/2018
2	AcidsIBA 01/2018 - 01/2010
2	telotristatIBA 01/2018 - 04/2015
2	Messenger RNA (mRNA)IBA 09/2016 - 01/2010
1	selpercatinibIBA 04/2022
1	pralsetinibIBA 04/2022
1	Tyrosine Kinase InhibitorsIBA 04/2022
1	Sorafenib (BAY 43-9006)FDA Link 04/2022
1	lenvatinibIBA 04/2022
1	CytokinesIBA 01/2022
1	Streptozocin (Streptozotocin)FDA Link 01/2022
1	cyclopropapyrroloindoleIBA 12/2021
1	AlbuminsIBA 10/2021
1	CholesterolIBA 10/2021
1	adavosertibIBA 01/2021
1	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 01/2021
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Programmed Cell Death 1 ReceptorIBA 11/2020
1	B7-H1 AntigenIBA 11/2020
1	Atropine FDA LinkGeneric 01/2019
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2019
1	Loperamide (Imodium)FDA LinkGeneric 01/2019
1	Diphenoxylate FDA LinkGeneric 01/2019
1	lutetium Lu 177 dotatateIBA 12/2017
1	Lutetium-177IBA 12/2017
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2017
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2017
1	Serum AlbuminIBA 01/2017
1	Essential Amino AcidsIBA 01/2017
1	TransferasesIBA 01/2017
1	Tryptophan (L-Tryptophan)FDA Link 01/2017
1	Alkaline PhosphataseIBA 01/2017
1	5-hydroxyindoleIBA 01/2017

Therapy/Procedure

28	Therapeutics 06/2022 - 01/2010
8	Drug Therapy (Chemotherapy) 05/2017 - 01/2009
2	Precision Medicine 07/2021 - 01/2021
1	Neck Dissection (Radical Neck Dissection) 04/2022
1	Thyroidectomy 04/2022
1	Drug Tapering 01/2022
1	Intravenous Infusions 12/2017
1	Brachytherapy 05/2017
1	Biological Therapy 01/2017